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At clinically relevant concentrations, this drug is approximately 85% bound to plasma proteins.
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Ativan is rapidly conjugated at its 3-hydroxy group into lorazepam glucuronide which is then excreted in the urine.
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The mean half-life of unconjugated Ativan in human plasma is about 12 hours and for its major metabolite, lorazepam glucuronide, about 18 hours.